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2.3.2. Target Engagement
- Nrf2‑Keap1 Disruption: Fluorescence polarization assay; Kᵢ = 0.9 µM.
- Mitochondrial respiration (Seahorse XF): ↑ basal OCR by 22 % at 1 µM; ↑ spare respiratory capacity by 31 %.
Conclusion